Pathways
STAT3 Mediated Tumor Escape
Description:
Immune cells in the tumour microenvironment not only fail to mount an effective anti-tumour immune response, but also interact intimately with the transformed cells to promote oncogenesis actively. STAT (Signal Transducer and Activator of Transcription) proteins act as a mediator of cytokine receptor signaling. This protein plays a role in transmitting the signals of growth factor receptors and is both cytoplasmic signaling molecules and nuclear transcription factors that ac...
References:
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STAT3, a Master Regulator of Anti-Tumor Immune Response.
Cancers (Basel). 2019 Aug 30;11(9):1280. doi: 10.3390/cancers11091280. -
The role of STAT3 in leading the crosstalk between human cancers and the immune system.
Cancer Lett. 2018 Feb 28;415:117-128. doi: 10.1016/j.canlet.2017.12.003. Epub 2017 Dec 6. -
Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma.
Mol Ther Oncolytics. 2020 Jun 5;18:100-108. doi: 10.1016/j.omto.2020.06.004. -
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.
Nat Rev Immunol. 2007 Jan;7(1):41-51. doi: 10.1038/nri1995.
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